Abstract

Insulin autoimmune syndrome is a rare cause of hyper insulinemic hypoglycaemia characterised by recurrent episodes of hypoglycaemia, elevated insulin and positive insulin autoantibodies in individuals not exposed to exogenous insulin. Approximately 80% of cases of insulin autoimmune syndrome coexist with other autoimmune diseases (Graves’ disease, systemic lupus erythematosus, rheumatoid arthritis, etc.). Medications, most commonly methimazole, may cause this syndrome. The differential diagnosis should include insulinoma and type B insulin resistance. The most commonly used test for diagnosis is the insulin autoantibody test. The aim of this case report was to present the insulin autoantibody syndrome developed by methimazole in a patient with Graves’ disease.

Keywords:Antibody; Insulin; Hypoglycaemia