Abstract

inflammation is the body’s defensive action against noxious stimuli. If the inflammation is aggravated chronically, by various agents such as chronic psychological stress, chemical agents, infectious agents, physical injury results in release of various inflammatory mediators such as cytokines, chemokine’s, growth factors from inflammatory cells activate key transcription factors such as NF-KB and STAT-3, results in tissue damage, immune modulation, and cellular changes involved in many diseases such as auto-immune disease, cancer, diabetes, Alzheimer’s disease, heart disease. Hence, chronic inflammation is considered as a basis for almost all diseases. This article briefs about the role of chronic inflammation in pathogenesis of various diseases.

LKeywords: Cancer; Auto-immune disease; Diabetes; NK-KB; STAT-3; Alzheimer’s disease; Heart disease; IL-1; TNF-α; IL-6