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Gerontology & Geriatrics Studies

Functional State of Endothelium in Aging

Submission: January 23, 2018; Published: March 23, 2018

Volume2 Issue5
March 2018


It is known that the older age is an independent non-modifiable risk factor for the development of cardiovascular pathology. An important role in the development of cardiovascular pathology in the older age is played by age-dependent changes in the structure and function of the endothelium [1]. The deterioration of the functional state of the endothelium an important role in the development of vascular pathology. Literatura suggest that endothelial dysfunction is a factor that precedes vascular pathology and provokes its development [2,3,4]. It was found that endothelial damage is a pathogenetic link of diseases of the cardiovascular system. Thus, changes in the endothelium of endocardial micro vessels lead to a decrease of myocardial fibers contractility [5], a clear relationship of pressure in the left ventricular cavity from nitric oxyde NO synthesis [6]. Endothelin-1 has been shown to be an autocrine-paracrine factor in the development of myocardial hypertrophy [7,8].

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