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Research & Investigations in Sports Medicine

High-Level Athletic Sprinters: Effects of Tolerance Training on DNA Damage, Acute Phase Proteins and Creatine Kinase

Submission: August 13, 2019;Published: August 29, 2019

DOI: 10.31031/RISM.2019.05.000608

ISSN: 2577-1914
Volume5 Issue2


Several studies have suggest that tolerance and speed resistence training are highly beneficial for highlevel athletic sprinters in relation to maximal running performance. However ROS generation by high intensity exercise contribute to oxidant accumulation and fatigue depressing the contractile function of myofibers so strength levels decrease, strength and power imbalances ≥10% are greater risk of injuries. Thus how to safely periodize trainings to obtein biopositive adaptations without favoring the prevalence of injuries?

Aim: In the present study, we aimed to evaluate the acute muscle and DNA damage, as weel as, kinetics of biomarkers signalling inflammation induced of tolerance training. Athlete: One male elite sprinter (World Champion with team Brazil 4x100m in 2019 & Brazil’s second best performance ever) PB 10’’02. Body characteristics: 21 years of age, 80kg body mass, 182.0cm of body height, 6.7 % fat mass.

Methods: Three Blocks with five sprints, distance (10/20/30/40/50m) sum 450m; five minutes of rest between blocks and 30 seconds between sprints. The blood samples were collected from the fingertip for [La-] assessment before and 30 seconds after sprints using aportable analyser and after 24h of training, samples were collected from the antecubital vein in EDTA-containing Vacutainer glass tubes. All measurements were obtained via automatic biochemical analyzer. Parameters: C-Reactive protein ultrasensitive; C-Reactive protein quantitative; CK; DNA damage.

Results: The main results were together with the increase in DNA damage in after sprints compared to resting conditions high levels of CK (approximately 700%) and acute phase proteins (approximately 300/400%) and recovery optimal in approximately 96h.

Conclusion: This study suggests that optimal training or competition for maximum performance (strength, power and speed) should be combined with the best recovery before the next maximum stimulus. Still suggesting that program success may be favored by monitoring the best internal load levels (Biomarkers and comet assay).

Keywords: DNA damage; Acute phase proteins; Biomarkers; Signalling inflamation; Periodization; Injuries

Abbreviations: ROS: Reactive Oxygen Species; CK: Creatine Kinase; [La-]: Blood Lactate Concentrations; (mmol.l-1): Millimole/Liter; Min: Minute; us-CRP: C-Reactive Protein Ultra-Sensitive; CRP: C-Reactive Protein Quantitative; PB: Personal Best; m: Meters; DNA: Deoxyribo Nucleic acid

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