Distal Fingertip Composite Graft in Amputation Salvaged through PGE-1 Assisted Treatment-A Case Report

Treatment of the distal fingertip amputation remains in the debate due to inconsistent feasibility for vascular anastomosis. Besides direct microvascular anastomosis, alternative surgeries have been in-troduced such as Hirase’s cooling principle [1], subcutaneous pocket graft [2], heteroditital transfer [3], and flap surgeries. These standard surgeries demand microsurgical infrastructure, as well as access to a medical institution within emergent gold hours. Prostaglandin E1 (PGE-1) has been reported to contribute to dilating peripheral vessels and to increasing blood supply, and it has been widely used for the postoperative care of anastomosis and composite grafts [4]. However, once the graft is devitalized after a replantation surgery, most commonly adopted treatment solution is amputation. Here we present a salvage treatment technique for distal fingertip amputation in an adult, by composite graft assisted by PGE-1. Abstract


Introduction
Treatment of the distal fingertip amputation remains in the debate due to inconsistent feasibility for vascular anastomosis. Besides direct microvascular anastomosis, alternative surgeries have been in-troduced such as Hirase's cooling principle [1], subcutaneous pocket graft [2], heteroditital transfer [3], and flap surgeries. These standard surgeries demand microsurgical infrastructure, as well as access to a medical institution within emergent gold hours. Prostaglandin E1 (PGE-1) has been reported to contribute to dilating peripheral vessels and to increasing blood supply, and it has been widely used for the postoperative care of anastomosis and composite grafts [4]. However, once the graft is devitalized after a replantation surgery, most commonly adopted treatment solution is amputation. Here we present a salvage treatment technique for distal fingertip amputation in an adult, by composite graft assisted by PGE-1.
A 51 years old man injured distal phalanx amputation of the left middle finger, for being hit by a steel pipe. He had sustained diabetes mellitus (DM), and 30 pack-year of smoking history. The amputation was obliquely traversing in the distal phalanx through the lunula of the nail bed. Distal interphalangeal (DIP) joint capsule was torn. The 2 nd finger's flexor digitorum profundus and the extensor digitorum was intact (Figure1). The distal phalanx was fractured. The distal fingertip composite graft was reattached onto the stump. Distal phalanx fracture was internally fixated with a K-wire. Culture study revealed no active infection. Needle puncture to the fingertip showed negative capillary perfusion. PGE-1 of Alprostadil was daily administered intravenously (Eglandin; Mitsubishi Tanabe Pharma Co., Osaka, Japan) 10µg/day for one week followed by the oral tablet of Limaprost intake (Opalmon, 10μg tid). The tissue presented mummification appearance since postoperative one week ( Figure 2). The mummified tissue was gradually substituted by regeneration tissue from the vital border. After one year of conservative treatment, the tissue regeneration was complete ( Figure 2). The active ROM of injured 3 rd finger DIP joint was 10-20 degrees. The skin sensation was preserved, without paresthesia nor dysesthesia. The patient returned to active manual work utilizing the recovered finger ( Figure 3).

Discussion
We observed delayed regeneration of amputated distal phalanx over early mummification following composite graft surgery, which was assisted by prostaglandin E1 administration. Composite graft alone has been reported to hardly survive in adult injuries, in contrast to young children. Survival of composite graft from amputation without microsurgical anastomosis has been reported. Cooling of the directly reattached amputated fingertip, without vascular anastomosis, enhances the graft survival. By lowering tissue metabolism in ice, the decay process would be minimized to sustain viability until vascular ingrowth forms an adequate channel [1][2][3][4][5][6]. Cooling principle enhances composite graft for the nose reconstruction [5].
Cap-technique in amputation around the lunula shortens soft tissue circumferentially on the proximal stump while preserving the germinal matrix (>2mm) for growth-bud of the nail. The distal amputated finger is shortened of the bone, then repaired over proximal stump close to the vascular rich periosteal tissue. As the nail grows, the finger heals after normal appearance, but some shortening of the length is expected [7]. We directly reattached the bone and soft tissue with minimal wound margin preparation, thereby preserved the original length. Vascular smooth muscle regulates the microcirculation through excitatory and inhibitory substances [10].
PGE-1 antagonizes microvascular constrictive responsiveness by angiotensin, vasopressin, and constrictor catecholamines [10]. PGE-1 shows diffuse dilating action upon all types of muscular micro-vessels, which decreases post arterial resistance to induce hypotensive effect [10]. PGE-1 application in hand angiography remarkably shows an increase of blood flow through the digital arteries via so dilatation leading to increasing of the volume of blood flow [13]. PGE-1 affects large vessels as well, as observed in the canine femoral artery [11]. Capillary permeability is increased by PGE-1 administration, synergizing vasodilatation in increasing oxygen supply [12]. Antithrombotic effect of PGE-1, supports microvascular replantation surgeries [4]. Ischemia-reperfusion injury of rat gastrocnemius muscle indicates enhanced blood flow with PGE-1 [14]. Microvascular anastomosis of ear amputation success-fully survives through PGE-1 administration [15].
If the digital arteries are damaged by distal phalanx amputation the blood supply mainly depends on collateral circulation. Without sufficient vasculature, the tissue became mummified. We administered PGE-1 intravenously for postoperative one week, then switched to oral regimen during following re-generation period. This case shows that even after early mummification following composite graft surgery on the distal phalangeal amputation, prudent, conservative treatment with patience, assisted by increased blood supply using PGE-1, can possibly lead to salvage regeneration of the composite graft. We speculate that while the mummified tissue function as the scaffold, the regeneration is encouraged by dilated peripheral vasculature and increased capillary permeability at the vital border. This treatment harbors limitations as well. Tissue damage needs to be individually assessed for planning the treatment. The salvage regeneration requires rather prolonged treatment duration, demanding patience of the patient. Some pulp hypotrophy accompanies after healing through the mummification. Although this is a time requiring treatment, when microvascular surgery is not feasible either from damage status, or medical environmental cause, we suggest that this patient treatment may well be considered as a treatment option before deciding amputation.