1Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University, Saudi Arabia
2Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Saudi Arabia
*Corresponding author:Shehab M Abd ElKader, Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah,Saudi Arabia
Submission: January 11, 2021Published: January 28, 2021
ISSN : 2578-0263Volume4 Issue5
Background: Oxidative stress is important in pathogenesis of diabetes complications. Limited research available regarding role of exercise in alleviation of oxidative stress in type 2 diabetes mellitus (T2DM).
Objective: The target of this study was compared response of insulin resistance and oxidative stress to aerobic versus resisted exercise training in T2DM patients.
Material and Methods: Eighty T2DM patients, the range of age ranged was 45 to 57 year and body mass index was 30 to 36kg/m2. Smoking, renal failure, heart failure, respiratory failure, hepatitis and pregnancy were the exclusion criteria. Participants randomly assigned equally into group (A) received aerobic treadmill exercise and group (B) received resistance exercise for 3 months.
Results: Following aerobic and resistance exercises, there was significant reduction in the mean values of Homeostasis Model Assessment-Insulin Resistance Index (HOMA-IR),conjugated dienes (CD) and malondialdehyde (MDA), in addition to significant elevation in the mean values of the quantitative insulin-sensitivity check index (QUICKI),glutathione peroxidase (GPx), superoxide dismutase (SOD) and glutathione (GSH). However, significant differences found between both groups after training.
Conclusion: Aerobic exercise is superior to resistance exercise in modulating insulin resistance and oxidative stress in type 2 diabetes patients.
Keywords: Aerobic exercise; Diabetes mellitus; Resisted exercises; Oxidative stress
Abbreviations: T2DM: Type 2 Diabetes Mellitus; QUICKI: Quantitative Insulin-Sensitivity Check Index; SOD: Superoxide Dismutase; HOMA-IR: Homeostasis Model Assessment-Insulin Resistance Index