Anti-Inflammatory Dietary Supplements in Prevention of Diseases

As our age advances, many changes are seen in our body, such as cellular changes, cardiovascular problems, cerebrovascular diseases, including cancer mediated by inflammation and their mediators such as free radicals (ROS,RNS), Cytokines, Transcription factors (NF-KB, STAT3) due to altered dietary patterns and digestive disorders. The disease pattern can be suppressed by including anti-inflammatory dietary supplements in our diet to prevent various diseases in geriatric peoples associated with inflammation. This article briefs about anti-inflammatory dietary supplements in prevention of diseases associated with inflammation in geriatric people.


Introduction
Most of all cancers are preceded by chronic inflammation is the body's response to any type of injury in the form of physical or chemical or thermal or infectious agents. Inflammation is an initial step to many type of diseases namely cardiovascular diseases such as Angina Pectoris, Myocardial Infarction, Neurovascular diseases such as Parkinsonism and Alzheimer's diseases. And, 25% of cancers are preceded by chronic inflammation such as oral cancer associated with oral potentially malignant lesions and conditions, Crohn's diseases, Prostate cancer, Breast cancer, cervical cancer, and Head and Neck cancer. Chronic inflammation is also considered as seventh hallmark of cancer [1][2][3][4][5].

Anti-inflammatory dietary supplements in prevention of diseases in geriatric people
Geriatric patients are prone to many diseases because of altered dietary patterns, reduced immune activity, altered cell proliferation and regeneration, muscle wasting, altered digestive pattern, and bone changes that lead to various complications.
Inflammation is preceded by most of all diseases. Hence, our aim is to suppress the inflammation by dietary supplements to prevent diseases for better health of an individual in geriatric peoples. Anti-inflammatory dietary supplements present in the food are Vitamin A, Vitamin C, vitamin E, Omega 3 fatty acids, Vitamin D, probiotics, curcumin [2].
Curcumin is apolyphenol, active component of Turmeric, extracted from the dried Rhizome of the Curcuma Longa plant. It has an anti-inflammatory property by down regulating key transcription factors of inflammation are NF-KB and STAT-3 mediated regulation of IL-1, IL-6, IL-8, TNF-α, 5-LOX, CXCR-4,COX-2, iNOS pro -inflammatory genes involved in various inflammatory reactions and cancer [2,6].

Sources:
Made from the Rhizomes of the plant Curcuma Longa.
Vitamin A, Vitamin C, Vitamin E are a vitamin, which neutralize the release of free radicals such as ROS, and RNS involved in oxidative stress induced cytokine activation and transcription factor that promotes DNA damage, cell aging, and cell death. They prevent the cell aging and cell death by reduction of inflammation associated with inflammatory conditions and cancer [1,9,10]. Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. It must contain a minimum 30x109CFU/gram.

Daily recommended dosage of vitamin
They have an anti-inflammatory role and CRP(C-reactive protein) level reduction related to strain specific such as Lactobacillus, Bifidobacterium, Saccharomyces, Enterococcus, and E. coli. It decreases Cytokine signaling such as TNF-α and increases in TGF-β, IL-10 acts as an anti-inflammatory role, inhibition of inflammation by inactivating JAK2 and STAT1/STAT3 transcription factor activation. It inhibits pathogenic enteric bacterial growth by decreasing luminal PH by Lactic Acid. Lowers the mutagenic and toxigenic reaction by its metabolic product, protection of intestinal barrier integrity and increases the absorption of calcium and other minerals, decrease inflammation associated molecules by production of short chain fatty acids (butyrate and lactate) [7,8].

Conclusion
Anti-inflammatory dietary supplements prevent various diseases in geriatric peoples by suppressing inflammatory mediators such as free radicals (ROS, RNS), Cytokines, growth factors, transcription factors associated with cardiovascular and gastrointestinal disorders, including cancer. Improving overall patient outcome and survival.