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COJ Biomedical Science & Research

A Potential Mechanism for Triggering Cytokine Storm in Covid-19 Patients

Submission: August 29, 2020; Published: September 03, 2020

Volume1 Issue2
September 2020


Infection with SARS-CoV-2 can result in severe disease characterized by cytokine storm and systemic inflammation. Despite huge efforts, there is only initial evidence that the humoral immune response and particularly the development of antibodies targeting SARS-CoV-2 nucleoprotein could play a decisive role for disease severity. Here, we present the opinion that severe Covid-19 disease could be co-triggered by anti-SARS-Cov-2 nucleoprotein antibodies, which are cross-reactive with human interleukin-11 and inhibit its anti-inflammatory and tissue protective function.


Keywords:Autoantibodies; Covid-19; SARS-CoV-2; Cytokine storm; Interleukin-11; Nucleoprotein

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