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Abstract

Biodiversity Online J

Preclinical Evaluation of Asparagus Racemosus Seed Oil Extract’s In Vitro Anti Salmonella Efficacy

  • Niladry SG1, Anubhav D2* and Mamta K3

    1Faculty of Pharmaceutical Science, Assam down town University, India

    2Department of Pharmacology, Maharana Pratap College of Pharmacy, India

    3Department of Pharmacy, Harcourt Butler Technical University, India

    *Corresponding author:Anubhav Dubey, Assistant Professor, Department of Pharmacology, Maharana Pratap College of Pharmacy, Kanpur, Uttar Pradesh, India

Submission: October 14, 2024;Published: November 19, 2024

DOI: 10.31031/BOJ.2024.05.000603

ISSN : 2640-9275
Volume5 Issue1

Abstract

Background: Growing resistance to commonly used medicines makes treating a life-threatening typhoidal salmonella infection increasingly challenging. The ability of the bacteria to produce biofilm contributes to this resistance. This work examined the in vitro anti-salmonella actions of the essential oil of Asparagus racemosus seeds.
Results: The effect was that the essential oil of Asparagus racemosus seeds (EOAR) stopped the growth of S. typhi with a zone of inhibition of 12±0.2 mm, compared to 30±0.3mm for ciprofloxacin. Minimum biofilm inhibitory values were 13.5mg/mL minimum bactericidal and minimum inhibitory concentrations were 24, 50, respectively. In S. Typhi, EOAR produced an efflux of potassium ions, inorganic phosphate, and pyruvic acid.
Conclusion: Essential oil of Asparagus racemosus seeds possesses in vitro anti-salmonella action.

Keywords:Essential oils; Asparagus racemosus; Salmonella Typhi; Typhoid fever

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