M-health Applied to Vaccinal Support: A review Integrative

The World Health Organization (WHO) advocates universal vaccination as a means of prevention of numerous diseases as 19 million children worldwide are not vaccinated or need extra immunization. According to WHO, vaccination “Saves millions of lives” and is recognized worldwide as one of the most successful and efficient prevention and at the lowest cost. According to data campaign foster equity and access to vaccinations, strengthen national immunization programs to reach populations with limited access to regular health services such as those on the outskirts urban, rural, border and indigenous communities, providing platform to raise awareness about the importance of immunization and maintain the topic on the political agenda [1]. Our vaccine coverage is still very heterogeneous, reflecting factors such as: great extent of our country, the lack of communication through an integrated system between the Health Care Units and the rework generated by the loss of vaccination cards. As well as lack of information, issues of accessibility and culture contribute to the reduction of adherents to health and should be worked out so as not to interfere so significantly with the vaccination coverage [2-5].


Introduction
The World Health Organization (WHO) advocates universal vaccination as a means of prevention of numerous diseases as 19 million children worldwide are not vaccinated or need extra immunization. According to WHO, vaccination "Saves millions of lives" and is recognized worldwide as one of the most successful and efficient prevention and at the lowest cost. According to data campaign foster equity and access to vaccinations, strengthen national immunization programs to reach populations with limited access to regular health services such as those on the outskirts urban, rural, border and indigenous communities, providing platform to raise awareness about the importance of immunization and maintain the topic on the political agenda [1]. Our vaccine coverage is still very heterogeneous, reflecting factors such as: great extent of our country, the lack of communication through an integrated system between the Health Care Units and the rework generated by the loss of vaccination cards. As well as lack of information, issues of accessibility and culture contribute to the reduction of adherents to health and should be worked out so as not to interfere so significantly with the vaccination coverage [2][3][4][5].
The development of new technologies, such as computerized registration systems vaccination with nominal data is essential for maintaining good quality [6][7][8][9][10], Computerized systems are useful for scheduling vaccinations, user identification, search for absenteeism and monitoring of coverage vaccination and adverse events following vaccination. Also, if related to other health and socio-demographic information systems, becomes a unique instrument for the planning and evaluation of public health actions, besides presenting information reliability, data accuracy and increased services provided by health professionals [9]. Computerized vaccine registration systems are an important tool for the increase and maintenance of vaccine coverage, generating information for data systems, and serve as reliable assessment tools for vaccine situation. The popularization of smart phones, smartphones, has been considered by many to be the most impacting technological revolution in recent times after the revolution caused by the Internet and social networks [1].

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M-Health can be defined as the use of communication technologies and information for the provision and improvement of health services. The mobility of this tool provides conditions for continuous health control and assessment, shows a new model that encourages healthy behaviors and helps in management and selfmanagement prevention or chronic conditions, among many other applications. The main feature of mobile applications is breaking mobility limitation, ease of use, interoperability and accessibility [2,4,7]. Another relevant aspect is the personality that the equipment provides to its users, considering that the professional can use his personal device, which he is used to dealing with daily [3].In addition, it can enable professionals to achieve more precision and agility in their work [7]. This review is an integrative review and part of a larger project aimed at development of new mobile technology for the area of vaccination in Public Health. Also, the review study is critical in identifying the gaps to be researched on the subject. Thus, the object of the research was to identify the state of art of mobile vaccination applications in other countries for prevention health through vaccination.

Materials and Method
In the first stage, the problem was identified and the guiding questions of the ( Figure 1)

A.
How are mobile apps being used to vaccination?

B.
What features are being implemented in this type of application?

C.
What application use can contribute to health research focused on vaccination? Which health professionals are benefiting from this kind of app? Following, the keywords "vaccine" were defined, "Mobile health", "apps" and "vaccination". After the search tests phase with the key words in the Capes journal platform, the following equation was defined: search: vaccines and "mobile app" / ("mobile" [tw] and "health [tw] or" mobile health "[tw] or "Apps" [tw] and ("vaccination" [mesh] or "vaccination" [tw]). We opted to perform the search database that returned a greater number of publications in the Capes search and that showed a greater relation with the researched theme. Thus, the following databases were defined: PubMed (Public Library of Medicine) and SciELO (Scientific Electronic Library Online). In the second stage, the criteria for inclusion and exclusion as described in Table 1. After reading and analyzing 109 returned titles and abstracts, the following publications that had the potential to answer the guiding questions and addressed the inclusion and exclusion criteria. Of the total publications found [11], remained for full reading. After careful analysis, it was observed that some references had the potential to answer the questions and were carefully analyzed. Subsequently, a thorough reading of the material was performed in full and extracted the concepts approached, comparing them and grouping them through the pre-established criteria [12][13][14][15][16][17][18][19][20].

Identification of pre-selected and selected studies
In this study, a total of 109 studies were found in the databases, of which 4 were from SciELO, 105 Portal portal PubMed. After the criteria of inclusion and exclusion resulted in 12 articles from Pubmed and 2 articles from Scielo. The selected works were summarized and classified according to the following criteria: year of publication, following distribution: 2018 (2), 2017 (5), 2016 (4), 2015 (1), 2014 (1) and 2013 (1); type of publication, being 14 articles, the remaining types were not used, such as: dissertation and course completion work [21].

Result and Discussion
After analyzing the data found, and using interpretive reading, emerged the following categories for mobile applications developed for health: "technology", "management" and "users".

Technology
Regarding the "technology" category, three publications were found: one developed an application to evaluate the use by health professional users and 21 others on an m-Health Pilot Study to promote HPV vaccination, 22 and the last, 23 bringing the contribution of the development of mobile applications as data from electronic records in order to increase information and reliability of yellow fever vaccines. In the study conducted in USA, 21 have been shown the requirements of the proposed assessment of the application in question, considering the features: functionality (which defines the capacity of the software providing functions that meet explicit and implicit needs); the reliability (ability of the software to maintain a specified performance level); usability (ability of the software to be understood, learned, operated and attractive to user); the efficiency (runtime and the resources involved); and the maintainability (ease of modification of the software, including both the functionality improvements or extensions for bug fixes, crashes or errors); in the work process of health professionals. It is also highlighted in which, in the evaluation of the characteristics of the software used, were obtained positive responses, as they were considered easily accessible and understandable, serving as a tool that assists the health manager in planning and decision-making on health staff in hospital institutions [22]. 2 O Koreano22 study that addressed the contributions and limitations of a mobile app for HPV control, pointed out limitations such as: education, safety, privacy and open standards.
However, he pointed out several advantages, such as: farreaching information, behavior change, a low cost. Also, scalability, technological autonomy, adaptation of the software to local language and culture, stability and impact on service quality of health. Thus, the study showed that the application points to political conditions and technologies to collaborate and dialogue with the principles of health prevention, as well as contributing to increased immunization coverage and cancer eradication in women [23]. Finally, the last study done in Sweden, 23 on the contribution and limitations of the mobile app for the control of yellow fever, dealt with the evaluation of an electronic documentation system -electronic registration, aiming at verify its technical quality and functional performance, based on the perception of computer specialists, nursing teaching assistants in order to identify possible technical failures and limitations for product improvements Final. Thus, according to the study, the developed system showed positive responses from some categories, such as reliability, suitability functional, usability, performance efficiency, compatibility, security, portability, providing answers to the assistance provided [23].

Management
Regarding the "Vaccination Management" category, four studies were elected which contemplated the use of mobile applications aimed at controlling the vaccination care. One of the selected studies, 24 deals with the idealization, execution and testing an app to seek continuous improvement of immunization coverage in Sichuan rural in China. In this app, doctors found it best to manage vaccines and with lower cost and time saving. However, it was difficult for doctors administer care to child patients who have left for other municipalities [24]. Another study 25 showing a practiceoriented device based on audience mapping, in this case measles and rubella in Kenya, aiming at vaccination with shorter campaign time. Like reported by the author, this app has been successfully used, including decreasing from 6 months to 4 weeks immunization coverage in the region [25]. Another study, 26 developed in Africa, made a vaccination app using SMS to remind and to guide health caregivers and the population on adherence to vaccination, in this case, the work was dedicated to the prevention of diseases with Focus on measles. This study resulted in decreased disease outbreak and increased vaccination coverage through post SMS reminders, waiting for vaccines and the dropout rate of African children [26]. Finally, the latest study [27] talks about the importance of bilingual (pan-free) mobile apps in helping to map provincial and territorial vaccines of immigrants in the Canada. This study showed that the use of vaccination applications assists in the disease control in the country and served as an instrument of adherence to vaccination campaigns across the country [27].

Users
In this category, seven publications were selected. One of the selected studies, 28 deals with the use of a mobile application to monitor vaccine coverage in the Pakistan. In this service, there are SMS messages directed to the user in order to inform you of the availability of vaccines and locations that are providing care. However, the problem of not receiving SMS by some due to internet failures and distance from large access centers [28]. Already in the study, 29 developed in Berlin, Germany, is the application of VaCcApp, which informs and guides users about vaccines, assists with reminders of family's immunization history, clarifies doubts regarding vaccines and health prevention, involves the family making them active agents in vaccine control of your kids. In addition, it motivates all users by assisting them with questions and next immunizations to be carried out [29]. The article, 30 conducted in Kenya in Africa, uses SMS to advise on vaccination campaigns and shows that they help significantly in coverage Copyright © Agnes Altmann TTEH.MS.ID.000536. 2(3).2020 and punctuality Vaccine. Also, it was noted that were previously there was coverage of 85% of population, the other 15% coverage was achieved through the use of SMS to reminders to users and control [30]. Another study, 31 conducted in Italy show that Mobile interventions bring information to parents about vaccination and can be used to increase knowledge through the dissemination of evidence users, reliability in prevention and decision-making assistance regarding the practice of vaccination. Success in designing and implementing this system information to users can be seen as an outline for system of standardization and computerization of immunization control through the psychological empowerment, risk perception, attitude, confidence and recommendation [31]. Another study, 32 conducted in Nigeria on the African continent, developed a application for use on mobile phones to remind users about the immunization schedule, providing subsidies for increased immunization coverage, optimizing o Services for greater absorption of routine immunization. One question raised in this article, addresses the need for ongoing training for users, so that they know how to use the tool and with this, a greater adherence to vaccination campaigns [32]. Another selected study, 33 talks about the use of vaccination application in the polio campaign in South Sudan where they had 95% immunization coverage in the country, using mobile technology. In this study, 34 an application was developed in Pune, India, to guide users about the influenza vaccination campaign. During this study, it was observed the decrease of time devoted to campaigns by health professionals, saving resources for the dissemination of the vaccination campaign, reduction of lags in health data management and analysis, improved data quality reported and fewer information errors [33][34][35][36].

Conclusion
In this study we presented the mobile health applications applied to vaccination identified in the scientific literature of several countries, according to the descriptors proposed. Based on the selected studies, the categories showed that Mobile applications have the functions not only of assisting professionals but also directly reach users. However, they need to be tested and evaluated to reduce constraints and increase contributions. Findings point to reduced number of works developed with this theme, considering the descriptors proposed, yet it is known that there has been growth over the years in relation to creation of mobile applications for use in vaccination. However, it is necessary that thematic scholars seek to standardize the descriptors in order to facilitate and provide a qualified search, thus allowing for greater visibility of the studies, it is also emphasized the importance of the dissemination and publication of these products.
In this study we presented the mobile health applications applied to vaccination identified in the scientific literature of several countries, according to the descriptors proposed. Based on the selected studies, the categories showed that Mobile applications have the functions not only of assisting professionals but also directly reach users. However, they need to be tested and evaluated to reduce constraints and increase contributions. Findings point to reduced number of works developed with this theme, considering the descriptors proposed, yet it is known that there has been growth over the years in relation to creation of mobile applications for use in vaccination. However, it is necessary that thematic scholars seek to standardize the descriptors in order to facilitate and provide a qualified search, thus allowing for greater visibility of the studies, it is also emphasized the importance of the dissemination and publication of these products. applications based on Scientific research is important because it directs the contents since they come from studies and analysis of professionals who know the real needs of users. Thus, it is understood that recognizing the needs of these users is essential for planning and implementing new consistent and appropriate manner, in accordance with the specific demands, tested in research and implemented in practice. For future work, it is suggested that, in addition to the applications that support professionals, it is necessary to develop more direct patient support applications. This will allow them to become more involved with aspects related to their own health, have access to information and, when necessary, receive remote support for selfcare and its treatment, acting with a self-management of health.