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Abstract

Significances of Bioengineering & Biosciences

A Secreted Protein in the Wnt Signaling Pathway-R-Spondin3: A Mini-Review

  • Open or Close Zhilong Chen1,2, Jian Zhang1, Qing Yang2* and Xiujun Fan1*

    1Shenzhen Institutes of Advanced Technology, China

    2Department of Clinic Veterinary Medicine, Human Agricultural University, China

    *Corresponding author: Xiujun Fan, Laboratory for Reproductive Healthy, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, China

    Qing Yang, Department of Clinic Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Nongda Road, Furong district, Changsha, China, Tel: 86-731-84613718; Email: qingyanghn@hunau.edu.cn

Submission: March 16, 2018; Published: May 22, 2018

DOI: 10.31031/SBB.2018.01.000518

ISSN 2637-8078
Volume1 Issue4

Abstract

R-spondins (Roof plate-specific Spondins, RSPOs) are secreted proteins, which act as activators of Wnt/β-catenin signaling and play roles in cell proliferation and differentiation, embryonic development, vasculogenesis as well as many human diseases. R-spondin3 (RSPO3) is a member of RSPOs family, containing two adjacent cysteine-rich furin-like domains, which act as an agonist in Wnt signaling. In this mini-review, we discuss and classify recent progress in understanding the protein functions of RSPO3 in embryonic development, vasculogenesis, and its role in cancers.

Keywords: RSPO3; Wnt signaling; Embryonic development; Vasculogenesis; Cancers

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