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Significances of Bioengineering & Biosciences

A Secreted Protein in the Wnt Signaling Pathway-R-Spondin3: A Mini-Review

  • Open or Close Zhilong Chen1,2, Jian Zhang1, Qing Yang2* and Xiujun Fan1*

    1Shenzhen Institutes of Advanced Technology, China

    2Department of Clinic Veterinary Medicine, Human Agricultural University, China

    *Corresponding author: Xiujun Fan, Laboratory for Reproductive Healthy, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, China, Tel: +86-755-86585220; Email:

    Qing Yang, Department of Clinic Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Nongda Road, Furong district, Changsha, China, Tel: 86-731-84613718; Email:

Submission: March 16, 2018; Published: May 22, 2018

ISSN 2637-8078
Volume1 Issue4


R-spondins (Roof plate-specific Spondins, RSPOs) are secreted proteins, which act as activators of Wnt/β-catenin signaling and play roles in cell proliferation and differentiation, embryonic development, vasculogenesis as well as many human diseases. R-spondin3 (RSPO3) is a member of RSPOs family, containing two adjacent cysteine-rich furin-like domains, which act as an agonist in Wnt signaling. In this mini-review, we discuss and classify recent progress in understanding the protein functions of RSPO3 in embryonic development, vasculogenesis, and its role in cancers.

Keywords: RSPO3; Wnt signaling; Embryonic development; Vasculogenesis; Cancers

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