Abstract

Objectives: To investigate infertility issues in Females and males due to sex hormones imbalance, Estimation of FSH, LH, Estradiol level in females infertile and Testosterone level in infertile males and females.

Methodology: It was a cross sectional study conducted at reproductive physiology/health, public health laboratory division, national institute of health Islamabad from December 2015 to September 2017. Study was carried out on 60 male and 60 female infertile patients. FSH, LH, estradiole were estimated for females and testosterone for males by Immunoenzymatic assay (ELISA). Data was analyzed by SPSS 16.

Results: Biochemical parameters for female population showed that 16.67% of sampled women indicated FSH level <4.5-11mIU/Ml while 40% with FSH level > 4.5-11mIU/Ml and 43.33% fall within normal range i.e., 4.5-11mIU/Ml. In the same manner, 10% of sampled female population was indicated with LH levels <2.12mlU/Ml, 36.57% with >10.89mlU/Ml and 53.33% within normal range i.e., 2.12-10.89mIU/Ml. Similarly, 30% women showed estradiol levels <40.7pg/ml while 16.67% were with >220.4pg/ml and 53.33% were found within normal range i.e., 40.7-220.4pg/ml. While the most common cause of male infertility by hormonal imbalance is due to either increased or decreased level of testosterone. 36.67% of sampled males indicated testosterone level less than normal i.e. <1.68ng/ml while 48.33% with testosterone level >7.81ng/ml and 15.00% fall within normal range i.e., 1.68-7.81ng/ml.

Conclusion: We concluded from our study that the most common cause of female infertility by hormonal imbalance is due to either increased or decreased level of follicle stimulating hormone (FSH) followed by estradiole and leutinizing hormone (LH). While the most common cause of male infertility by hormonal imbalance is due to either increased or decreased level of testosterone.

Keywords: Estradiol; Follicle stimulating hormone (FSH); Luteinizing hormone (LH) and testosterone hormones; Infertility