Abstract

The rise in concentration of (TSH) levels, natural goitrogenic substances, iodine deficient nutrition, lack of selenium and iron are associated with the enlargement of the thyroid gland that is referred to goiter. The symptoms of goiter have been observed in hypothyroid, hyperthyroid and euthyroid patients. The study has documented 354 patients of goiter belonging to various age groups and 50 normal control individuals. The data had evaluated through chi (Χ2) Calculations based on the normal concentration of thyroid function tests ranging (0.27-4.2 μIU/ml). Hypothyroidism and hyperthyroidism can be accurately diagnosed with laboratory tests performed at NORI. The patients with age group 1-20 years, 20-40 years, 40-60 years and 60-80 years were documented in age group 1, 2, 3 and 4 respectively. The required data was collected with the help of clinicians at Nuclear Medicine, Oncology and Radiotherapy Institute (NORI) and entered in the Performa. The diagnostic evaluation relating to functional and morphological characterization has examined through serum TSH concentration and imaging. The result shows non-significant difference between hypothyroid and hyperthyroid patients of diffuse goiter and control group individuals. The study has concluded that the prevalence of goiter is not dependent on the higher and lower concentration of TSH.

Abbreviationsc: TSH: Thyroid stimulating hormone; χ2 : Chi-square; T4: Tetra iodothyronine; T3: Triiodothyronine; TFT’s: Thyroid Functions Tests; TRH: Thyrotropin Releasing Hormone; FT4: Free Tetraiodothyronine; FT3: Free Triiodothyronine; SCH: Subclinical Hypothyroidism; TPOAb: Thyroid Peroxidase Antibody