Abstract

The presence of solitary or multiple nodules including both hot and cold nodules in case of nodular thyroid disease is due to the risk of malignancy, toxicity, and local compressive symptoms. It is characterized by the number of separate lumps (nodules) in the enlarged thyroid gland at the age of puberty. Both hypothyroid and hyperthyroid patients are observed to have abnormal TSH concentrations. The comprehensive survey of 234 patients of nodular goiter carried out and evaluated statistically through chi (Χ2) Calculations in order to investigate various thyroid dysfunctioning based on the normal concentration of thyroid function tests. Hypothyroidism and hyperthyroidism can be accurately diagnosed with laboratory tests performed at Nuclear Medicine, Oncology and Radiotherapy Institute (NORI) Islamabad and other laboratories of Pakistan. The data along with detailed history was collected with the help of clinicians in NORI and entered in the Performa. TSH levels ranging from 0.27-4.2 μIU/ml was considered as normal for the diagnosis in thyroid function tests (TFTs). Chi-square test was used to find the significance of study parameters on categorical scale between two or more groups. The diagnostic evaluation relating to functional and morphological characterization has examined through serum TSH concentration and imaging. Non-significant difference between hypothyroid and hyperthyroid patients of nodular goiter versus control group individuals was observed. The study has concluded that the prevalence of nodular goiter may be dependent on the higher and lower concentration of TSH.