Abstract

Research in Medical & Engineering Sciences

Effect of Oral Sub-Lethal Dose of Abamectin in the Rat: Serum ALT, AST, Urea, Creatinine and Histopathological Changes

  • Open or Close Mohey Mekawy1, Ashur H Khali2 and Hussein A Kaoud3*

    1Department of Forensic Medicine, Cairo University, Egypt

    2Agency of Forensic Medicine, Egypt

    3Department of Veterinary Hygiene and Environmental Pollution, Cairo University, Egypt

    *Corresponding author: Hussein A Kaoud, Department of Veterinary Hygiene and Environmental Pollution, Faculty of Veterinary Medicine, Cairo University, Egypt, Email: ka-oud@outlook.com

Submission: January 08, 2018; Published: January 30, 2018

ISSN : 2576-8816
Volume3 Issue3

Abstract

In this study, the effect of ABA on serum ALT, AST, urea and creatinine were studied as well as histological changes in the liver and kidneys. Group 1 animals were given with abamectin at a dose of 30mg/kg B. Wt. (1/10 LD50), double oral doses \week for 15 days and one month. Group 2 animals were given with abamectin at a dose of 30mg/kg B. Wt. (1/10 LD50), double oral doses \week for 15 days and one month.

The results of the current study showed that in the administration of abamectin in 1/10 LD50, for 15 days and one-month (group 1 and 2) significantly increased plasma levels of ALT, AST, urea and creatinine in male rats treated, compared with control group. Changes in ALT and AST levels vary depending on exposure time, where an increase in enzyme activity was observed in animals of group 2 compared with that group 1.

The results also showed that the abamectin tended to cause a significant change in the liver and kidney rat. The permeability of the leukocyte pockets, congested blood vessels in the portal tract, destruction of some liver cells and vacuolation of liver cells. Significant necrosis of tubular cells, glomerular atrophy, and interstitial infiltration areas of round cells were found.

Keywords: Abamectin; Oral sub-lethal dose; ALT; AST; Urea; Creatinine; Histopathological changes

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