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Abstract
Orthopedic Research Online Journal
Novel Local Bone Void Filling Antibiotic Carriers for the Treatment of Bone Infection
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Open or Close Raquib Hasan and Amanda Brooks*
Department of Pharmaceutical Sciences, North Dakota State University, USA
*Corresponding author: Amanda Brooks, Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND, 58102, USA
Submission: November 11, 2017; Published: December 20, 2017
ISSN: 2576-8875Volume1 Issue5
Abstract
To combat acute and chronic osteomyelitis, particularly implant-associated osteomyelitis, local antibiotic delivery from a biodegradable carrier is favorable over systemic antibiotic treatment. Not only can this help to achieve high local concentration over a desired therapeutic window, but it can also fill the void space left after surgical debridement.This mini review will briefly consider the advantages and disadvantages of synthetic polymer-based materials, ceramics, and calcium-based materials such as calcium phosphate (CP), calcium sulphate (CS), and bioglass, which can be used as a local antibiotic carrier as well as a bone void filler.
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