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Abstract

Open Journal of Cardiology & Heart Diseases

CRP3/MLP as a New Target to Prevent Vein Graft Failure

  • Open or Close Luciene C G Campos1, Wilson Barros Luiz1 and Valério Garrone Barauna2*

    1Department of Biological Science, Santa Cruz State University, Brazil

    2Department of Physiological Sciences, Federal University of Espirito Santo, Brazil

    *Corresponding author: Valério Garrone Barauna, Department of Physiological Sciences, Laboratory of Molecular and Cellular Physiology, Health Sciences Center, Federal University of Espírito Santo, Av. Marechal Campos, 1468 -Maruípe-Espírito Santo-Vitória, 29043900, Brazil

Submission: March 09, 2018; Published: June 19, 2018

DOI: 10.31031/OJCHD.2018.02.000534

ISSN: 2578-0204
Volume2 Issue2

Abstract

Coronary artery bypass graft surgery is the most frequently performed surgical intervention for relieving consequences associated with myocardial infarction. Despite its efficiency and advances in the methodology of collection, preservation and early onset antithrombotic treatment, vein graft failure is estimated between 15 and 30% during the first year. After 10 years of surgery, only 50% of these grafts are free of significant stenosis. Thrombosis, intimalhyperplasia, and accelerated atherosclerosis are the primary events pathophysiological of vein graft [1,2]. Successful vein graft adaptation is a complex process. In the vein graft procedure, a vein segment is submitted to arterial haemodynamic condition and thus genes associated with venous and arterial identities can be modulated as triggers to the adaptive response. Biomechanical factors, such as shear stress and stretch, are responsible for disturbed flow patterns which make the vein susceptible to remodeling within timal thickening which reduces grafts patency [3].

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