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Abstract
Open Journal of Cardiology & Heart Diseases
On the Mechanism of the Cardiac L-type Calcium Channel in Cardiac Cells
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Open or Close Mark IM Noble*
Department of Medicine and Therapeutics, University of Aberdeen, UK
*Corresponding author: Mark IM Noble, Department of Medicine and Therapeutics, Cardiovascular Medicine, University of Aberdeen, Aberdeen, UK
Submission: August 07, 2017; Published: May 11, 2018
ISSN: 2578-0204Volume2 Issue1
Abstract
A hypothesis is presented which suggests that the cardiac L-type calcium channel opens in a stochastic fashion as the calcium channel protein complex moves around in the lipid of the outer leaflet of the sarcolemma. Opening occurs [1] when there is release of calcium ions that are bound in the polarised state to anionic phospholipid of the inner leaflet, the release being a consequence of proton penetration into the sarcolemma upon depolarisation and [2] a calcium channel protein complex moves into the same site on the outer leaflet.
Keywords: Excitation-contracation coupling; Sarcolemmal anionic phospholipid; Stochastic behaviour
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