- About Us
- Guidelines
-
The Author ensures that the research has been conducted responsibly and ethically with adherence to all relevant regulations. read more..
- For Authors
- For Reviewer
- Manuscript Guidelines
- Membership
-
- Journals
- Reprints
- e-Books
- Videos
- Indexing
- Contact Us
COVID-19
- Submissions
Abstract
Open Journal of Cardiology & Heart Diseases
On the Mechanism of Depolarisation and Repolarisation in the Sino-Atrial Node
-
Open or Close Mark IM Noble*
Department of Medicine and Therapeutics, University of Aberdeen, UK
*Corresponding author: Mark IM Noble, Department of Medicine and Therapeutics, Cardiovascular Medicine, University of Aberdeen, Aberdeen, UK
Submission: January 12, 2018; Published: January 25, 2018
ISSN: 2578-0204Volume1 Issue2
Abstract
In 16 traces of spontaneous activity of sinus node pacemaker cells of various species from mouse to man, the charge change during repolarisation was between 3 and 8 times (mostly between 3 and 4 times) that recorded during the pacemaker current (“funny current”, If). This finding is incompatible with the necessity for a steady state of ionic movement in and out of the cell - the ionic balance; there is a deficit of outward positive ion movement sufficient to complete repolarisation. It is postulated that the deficit is solved by generation of electrical energy in the form of electrons by oxidative phosphorylation of mitochondria.
Keywords: Heart; Cardiac pacemaker; Funny current; Ionic balance
Editor In Chief
.jpg)
Signup for Newsletter
Quick Links
Editorial Board Registrations
Submit your Article
Best Paper of the Volume
Reprints
Refer a Friend
Advertise With UsOur Recent Edition
.jpg)
Top Editors
.jpg)
.bmp)
.jpg)
.png)
.jpg)
.png)
.png)
.png)
Financial Support
Sponsors
Latest e-Books
Latest Video
a Creative Commons Attribution 4.0 International License. Based on a work at www.crimsonpublishers.com.
Best viewed in 
| Above IE 9.0 version