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Abstract

Open Access Biostatistics & Bioinformatics

Phylogenetic Methods and its Applications

Submission: December 16, 2017; Published: February 06, 2018

DOI: 10.31031/OABB.2018.01.000505

ISSN: 2578-0247
Volume1 Issue1

Abstract

The phylogenetic tree portrays a relationship between sets of species and represents a model of molecular evolution. The current forms of species retain many of their ancestral features, some of which gradually change to help these species adjust to their environment. We provide a review of phylogenetic construction and validation methods and its application in cancer analysis. The need of alignment free methods for sequence comparison is also explored as an alternative to alignment based methods.

Keywords: Phylogenetics; Sequence comparison; Tree validation; Alignment free methods

Abbreviations: DNA: Deoxyribonucleic Acid; RNA: Ribonucleic Acid; MAST: Maximum Agreement Subtree

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