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Modern Research in Dentistry

Matrix Metalloproteinase Gene Polymorphisms in Periodontitis in Taiwanese Population

  • Open or Close Chi-Cheng Tsai1,2*, Yu-Shian Chou4, Ying-Chu Lin3, Ya-Ping Ho3,4, Yi-Min Wu3,4 and Kun-Yen Ho3,4

    1School of Dentistry, College of Oral Medicine, Chung Shan Medical University, Taiwan

    2Department of Dentistry, Chung Shan Medical University Hospital, Taiwan

    3School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Taiwan

    4Department of Dentistry, Kaohsiung Medical University Hospital, Taiwan

    *Corresponding author: Chi-Cheng Tsai, School of Dentistry, College of Oral Medicine, University Hospital, Chung Shan Medical University, Taiwan, Email:

Submission: November 07, 2017; Published: November 29, 2017

Volume1 Issue2


Periodontitis is an inflammatory disease associated with bacterial infections. In severe cases is accompanied by the loss of alveolar bone with eventual exfoliation of the teeth [1]. Although bacteria are essential to the induction of the disease, individual susceptibility to periodontitis seems to be of major importance in determining the manifestation and progression of the disease [2]. Bacterial pathogens involved in periodontal diseases exert a part of their destructive effect by triggering and inducing host cells to elevate their secretion of matrix metalloproteinases (MMPs). MMPs comprise a structurally and functionally related family of proteolytic enzymes, which play an essential role in tissue remodelling and repair associated with development and inflammation [3]. Studies have focused on the role of MMPs in the pathogenesis of periodontal diseases [4-6].

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