Abstract

Pharmacovigilance is a clinical discipline in its own right. It contributes to an ethos of safety and serves as an indicator of the standards of clinical care practiced within a country. In the last decade the field of neuroscience has accepted behavioral research as a necessary part of studies that previously contained only cellular or histologic findings. Behavioral assessment has become a part of Pre-clinical Pharmacovigilance. Pharmaceutical companies and toxicologist find themselves needing to comprehensively assess drug efficacy in a high throughput fashion, something that can take years to do in both humans and non-human primates over the course of the life span. Here transgenic mice have contributed enormous amount of data to this subject.