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Abstract

Modern Approaches in Drug Designing

Preparation, Characterization and Comparison of In-Vitro Dissolution Data of Montelukast Sodium Tablet with the RLD Product

  • Open or Close Tushar Saha1* and Md Abdullah Al Mizan1

    1Department of Pharmaceutical Technology, University of Dhaka, Bangladesh

    *Corresponding author: Tushar Saha, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

Submission: June 18, 2018; Published: July 20, 2018

DOI: 10.31031/MADD.2018.02.000536

ISSN: 2576-9170
Volume2 Issue3

Abstract

The aim of the present investigation was to prepare and characterize montelukast sodium tablet and then compare the in vitro dissolution data with RLD product. Wet granulation technology was applied for both intra and extra granular part of the tablet. Physicochemical properties of the tablet were performed according to the official method of pharmacopoeia and obtained result was satisfactory. The f2 values of in vitro dissolution study was found after 45 minutes were 53.16 in 0.5% SLS medium, 70.17 in 0.1N HCl medium (pH 1.2), 99 in acetate buffer medium (pH 4.5) and 82.73 in phosphate buffer (pH 6.8). From the obtained f2 value it was clear that, prepared montelukast sodium tablet was satisfactory in case of dissolution as it was over 50 in every medium.

Keywords: Montelukast sodium; RLD product; f2 value

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