Abstract

The neurodegeneration is process of the progressive loss of structure and/or functions including death of neurons. Many neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), Parkinson’s, Alzheimer’s, and Huntington’s diseases occurred as a result of neurodegenerative processes. These neurodegenerative diseases are constantly on rise worldwide. Various transcription factors involved in the pathogenesis of neuroinflammatory degenerative disorders. The involvement of the latent and active transcription factors are the current focus and target for researchers to work in this area of research. The current review is focused on the regulation of various transcription factors as a therapeutic target for these noncurable diseases.

Keywords: Drug design; BIOS; FOS; Molecular docking; Pharmacophore