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Modern Approaches in Drug Designing

Transcription Factor as Therapeutic Targets for Neurodegenerative Disorders: An Update

  • Open or Close Rishi Pal* and Prafulla Chandra Tiwari

    Department of Pharmacology & Therapeutics, King George’s Medical University, India

    *Corresponding author: Rishi Pal, Department of Pharmacology & Therapeutics, King George’s Medical University, India, Email:

Submission: February 6, 2018; Published: April 02, 2018

DOI: 10.31031/MADD.2018.01.000525

ISSN: 2576-9170
Volume1 Issue5


The neurodegeneration is process of the progressive loss of structure and/or functions including death of neurons. Many neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), Parkinson’s, Alzheimer’s, and Huntington’s diseases occurred as a result of neurodegenerative processes. These neurodegenerative diseases are constantly on rise worldwide. Various transcription factors involved in the pathogenesis of neuroinflammatory degenerative disorders. The involvement of the latent and active transcription factors are the current focus and target for researchers to work in this area of research. The current review is focused on the regulation of various transcription factors as a therapeutic target for these noncurable diseases.

Keywords: Drug design; BIOS; FOS; Molecular docking; Pharmacophore

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