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Modern Approaches in Drug Designing

A Comparative Study between Prostaglandin 2α and Methyl Ergometrine in the Active Management of Third Stage of Labour

  • Open or Close Sabha Malik1*, Cimona Lyn Saldanha1 and Fida Md2

    1Department of Obstetrics and Gynaecology, Sher-i-Kashmir Institute of Medical Sciences, India

    2Medical officer, JLMN Hospital, India

    *Corresponding author: Sabha Malik, Department of Obstetrics and Gynaecology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu & Kashmir, India; Email:

Submission: December 12, 2017; Published: January 30, 2018

DOI: 10.31031/MADD.2018.01.000522

ISSN: 2576-9170
Volume1 Issue5


Background: Post-partum hemorrhage (PPH) which occurs in upto 18% of the births carries with it a 3% risk of death and is a largely preventable event.

Material and Methods: A prospective study was carried out in the Post Graduate Department of Obstetrics and Gynecology, SKIMS, over a period of one and half years. A total of 200 women were enrolled in the study and were divided into two groups. In Group I Prostaglandin 2α was given intramuscularly and in group II methyl ergometrine was given intravenously at the time of delivery of anterior shoulder of the foetus. The main outcome measures that were studied included the duration of third stage of labour, amount of blood loss and a drop in hemoglobin and haematocrit concentration from before delivery to 24 hrs after delivery.

Results: It was observed that the mean duration of third stage of labour was significantly shorter in Group I as compared to Group II. The mean blood loss was also significantly less in the Group I as compared to Group II. The percentage drop in hemoglobin in Group I was significantly lesser than in Group II.

Conclusion: It was concluded that I/M Prostaglandin 2α is a better alternative to I/V methyl ergometrine in the active management of third stage of labour as it reduces blood loss significantly.

Keywords: Uterotonics; Labor; Post-partum hemorrhage; Methyl ergometrine; Prostaglandin 2α

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