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Abstract
Modern Approaches in Drug Designing
4-((Bis (2-Chloroethyl) Amino) Methyl)-2H-Chromen- 2-Ones as Antifungal, Cytotoxic, Anti-tubercular and Antimicrobial Agents
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Open or Close Naik RJ1, Revankar HM1, Kulkarni MV1*, Pai KSR2 and Nayak PG2
1Department of Chemistry, Karnatak University, India
2Department of Pharmacology, Manipal University, India
*Corresponding author: MV Kulkarni, PG Department of Chemistry, Karnatak University, Dharwad- 580003, Karnataka, India
Submission: October 12, 2017; Published: December 11, 2017
ISSN: 2576-9170Volume1 Issue3
Abstract
4-((Bis(2-chloroethyl)amino)methyl)-2H-chromen-2-ones synthesised from 4-Bromomethyl coumarins were found to exhibit a broad spectrum antifungal activity with IC50 of 0.2μg/mL. They exhibited moderate activity against HeLa and MCF-7 cell lines. They exhibited promising activity against M.tuberculosis and bacterial strains. Cytotoxic studies revealed that all the screened compounds showed IC50 higher than 5μg/mL against V79 and HBL100.
Keywords: 2H-chromen-2-ones; Cell line screening; Anti-tubercular; Anti-microbial; Anti-fungal
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