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Abstract

Modern Approaches in Drug Designing

Flavonoids-The Most Potent Poly-phenols as Antidiabetic Agents: An Overview

  • Open or Close Saritha Marella*

    Department of Nanotechnology, Acharya N.G. Ranga Agricultural University, India

    *Corresponding author: Saritha Marella, National Post doc fellow, Nanotechnology Laboratory, Regional Agricultural Research Station, Acharya N.G Ranga Agricultural University, Tirupati- 517502, A.P, India

Submission: October 24, 2017; Published: December 06, 2017

DOI: 10.31031/MADD.2017.01.000513

ISSN: 2576-9170
Volume1 Issue3

Abstract

Diabetes mellitus is a metabolic disorder of carbohydrate, lipid and amino-acids characterized by polyuria, polyphagia, polydypsia, blurred vision etc. It is the most prevailing disease affecting nearly 285 million people worldwide and is expected to rise to 438 million by 2030. In spite of numerous drugs currently available in the treatment of diabetes, herbal products tend to gain much importance over any other due to less/minimal adverse effects in recent decades. Around 60% of the world’s population is using medicinal plants as a traditional medicine out of which India is major contributor. Polyphenols, in particular flavonoids can be suggested as better therapeutic agents in the management of diabetes mellitus and also chronic complications associated with the disorder. In the present review, focus is made on various flavonoids, their chemical nature and their mechanisms of action from various plant sources in overcoming hyperglycemia and its associated complications.

Keywords: Antidiabetic; Flavonoids; Glucose tolerance; Hyperglycemia; Poly-phenols

Abbreviations: AGEs: Advanced Glycation End Products; CAT: Catalase; DM: Diabetes Mellitus; GLUT4: Glucose Transporter4; GPx: Glutathione Peroxidise; HbA1c: Glycated Haemoglobin; PPARγ: Peroxisome Proliferator-Activated Receptor Gamma; ROS: Reactive Oxygen Species; SOD: Super Oxide Dismutase; SREBP-1c: Sterol Regulatory Element-Binding Transcription factor 1

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