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Abstract
Investigations in Gynecology Research & Womens Health
Humanized GHR106 Monoclonal Antibody is a Biosimilar GnRH Antagonist
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Open or Close Gregory Lee*
UBC Center for Reproductive Health, Canada
*Corresponding author: Gregory Lee, UBC Center for Reproductive Health, Vancouver, 9117 Shaughnessy Street, Vancouver, Canada, V6P 6R9, Canada, Tel: 604-325-4602/778-322-4651; Email: leecyg@gmail.com
Submission: April 01, 2018; Published: April 06, 2018
ISSN: 2577-2015Volume1 Issue5
Abstract
GHR106 is a monoclonal antibody generated against human GnRH receptor. The humanized forms of GHR106 exhibit almost identical biological properties to those of decapeptide GnRH antagonists such as Antide and Cetrorelix. The biosimilarity between these two GnRH receptor ligands was based on the studies of (1) binding affinity and specificity as well as immunohistochemical staining, (2) induced apoptosis to cancer cells and (3) effects of ligand- receptor bindings on gene regulations of cancer cells.
keywordsBiosimilar GnRH antagonist; GnRH antagonist; Antide; Cetrorelix; Humanize; GHR106 monoclonal antibody; GHR106 of IgG4 isotype
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