Intestinal Microbiota and Its Link with Mind and Heart

Summary A mini review about how the Intestinal Microbiota (IM) is linked to the mind and heart is carried out. It is pointed out how once IM inflammation (Dysbiosis) generated, a series of mechanisms, immunological, neuronal and endocrine, that affect host phenotypes are triggered. The interpretation of what the gut-microbiota-brain axis is deepened. (GBA), and it is exemplified how, through bidirectional communications with the Intestinal Microbiota, a series of changes, which impact human health, are translated. Likewise, 10 conclusions are proposed on diverse topics, because the IM not only relates to the mind-heart binomial, but it has to do with many organs and consequently with many sufferings.


GMR.000571. 3(5).2019
which translates into dysbiosis. And finally, in psychological, gastrointestinal, skin conditions, etc [8]. Not only does Microbiota Disease affect the mind and heart, but it does so in other organs, such as the liver. In it, hepatocellular cancer, steato-hepatitis, non-alcoholic fatty liver and other conditions may appear, so it is recommended to rationalize the administration of antibiotics and some other toxic components that affect the liver [9]. A sufferings of the mind as it is, Autism Spectrum Disorder (ASD), has been determined by Microbiota Disease. The inflammation of this superorgan generates this complex human behavior, as has been observed, in mice transplanted with intestinal microbiota, from patients with ASD [10]. Evidence has continued to appear that dysbiosis is closely related to the mind-heart binomial and bidirectional signals have been present in this interesting communication.
Not only has it been written about conventional disorders of the effect of the microbiota, we also read articles of transplanted patients, as a final methodology, in terminal disease. Due to the above and the complications inherent to these methods, IM has been studied and, significant changes have been observed in transplanted patients, so these changes can be used as prognosis. Concomitantly, they have turned their eyes to the Intestinal Microbiota Transplantation (IMT) and, to the use of prebiotics and probiotics in this type of patient [11]. And not only has Intestinal Microbiota Transplantation been explored in donors without special diets, but it has been done in Beganos, with flattering results [12]. Its evident that Intestinal Microbiota Transplantation (IMT) improves numerous neurological problems, through the correction of dysbiosis. It has been considered that this occurs, provided that the functions of immune cells and brain drainage are not compromised [13].

1.
The intestinal microbiota, boosts host metabolism; confers resistance to infections, inflammatory processes, the development of neoplasms and autoimmunity. It promotes endocrine functions and collaborates with neurological function, through the so-called "gut-microbiota-brain axis" [14].

2.
IM is linked to the mind and heart, through signals similar to those produced by hormones, by affecting the host's metabolic phenotypes [15].

3.
Intestinal Microbiota Dysbiosis generated by antibiotics stimulates the release of cytokines, which aggravate the cardiac lesion [16].

4.
On the intestine-microbiota-brain axis, there are interactive and parallel channels, which communicate the Intestinal Microbiota with the brain [17].

5.
The cure of both mental and gastrointestinal diseases will be closer, when detected, why and where in the transmission of GBA, there is involvement [18].

6.
The Intestinal Microbiota Disease affects many other organs, such as the liver, so it´s recommended to rationalize the administration of antibiotics and some other toxic components that affect the liver gland [19].

7.
Autism Spectrum Disorder has been determined, which is generated by Intestinal Microbiota Disease [20].

8.
They have turned their eyes, towards the Intestinal Microbiota Transplant and, to the use of prebiotics and probiotics, in transplanted patients [21].

9.
Flattering results have been observed in Beganos, which has been used as donors of Intestinal Microbiota [22].