Crimson Publishers Publish With Us Reprints e-Books Video articles

Abstract

Gerontology & Geriatrics Studies

Changes in Melatonin Biorhythms and Immune- Neuroendocrine Interactions in Oncological Patients of Different Ages

  • Open or Close Labunets Irina F*

    Cell and Tissue Technologies Department, Experimental Modeling Laboratory, Ukraine

    *Corresponding author: Irina Labunets, Experimental Modeling Laboratory, Cell and Tissue Technologies Department, Institute of Genetic and Regenerative Medicine National Academy of Medical Sciences of Ukraine, Vyshgorodskaya Street 67, PO Box: 04114, Kiev, Ukraine, Tel: 80444687550; Fax: 38044 4687541; Email: irina_labunets@uke.net

Submission: January 18, 2018; Published: April 27, 2018

DOI: 10.31031/GGS.2018.03.000557

ISSN: 2578-0093
Volume3 Issue2

Abstract

The frequency of tumors in aging increases worldwide. The use of chronobiological approaches in studying circadian and circannul rhythms of various organism functions may be perspective for effective diagnosis, prevention and treatment of oncologic patients of different age. This review presents the data about changes of the basic components in control system of the biorhythms in aging and tumor development. We present the results of our study about the biorhythms of the immune system in healthy adult subjects and their changes in aging and cancer as well as their links with the disturbances in rhythmicity of thymic hormone thymulin. The role of disturbances in the interrelations of biorhythms melatonin and cortisol levels for development of desynchronosis thymulin and immune system functions in aging and cancer are underlined.

The importance of using chronobiological approaches for estimation of changes in the immune and neuroendocrine system in the oncopatients and the use of melatonin as synchronizing agent in the their basic treatment schemes is substantiated. Schemes of melatonin administration should be based on age-related changes of the sensitivity immune and endocrine systems to its influence.

Keywords: Biorhythms; Melatonin; Thymulin; Cortisol; Immune system; Age; Oncological patients

Get access to the full text of this article