Crimson Publishers Publish With Us Reprints e-Books Video articles

Abstract

Gerontology & Geriatrics Studies

Chronic Psychological Stress Induced Microbial Imbalance (Dysbiosis) Mediated Auto-Immune Diseases - A Current Concept

  • Open or Close Shrihari TG*

    Department of Oral Medicine and Oral Oncology, Krishnadevaraya College of Dental Sciences, India

    *Corresponding author: Shrihari TG, Assistant professor, Department of Oral Medicine and Oral Oncology, Krishnadevaraya College of Dental Sciences, Bengaluru-562157, India

Submission: April 13, 2018; Published: April 17, 2018

DOI: 10.31031/GGS.2018.03.000551

ISSN: 2578-0093
Volume3 Issue1

Abstract

Chronic psychological stress induced release of CRH (corticotrophic releasing hormone) from hypothalamus activates HPA-axis (hypothalamo pituitary adrenal axis) through autonomic nervous system release cortisol, ACTH (Adrenocorticotrophic releasing hormone), and noradrenaline neuropeptides. These neuropeptides also activates inflammatory mediators such as IL-1 β, TNF-α, IL-6, pro-inflammatory cytokines and COX-2 inflammatory mediator from inflammatory cells (6-9).

Get access to the full text of this article