Ghanem’s New Discoveries in Medicine, Physiology and Urology and Nephrology?

The last 32 years of my career life were spent in investigating and reporting these articles. [1-4] The articles recognize two new types of socks and its treatment, proves that Starling’s law for the capillary interstitial fluid transfer is wrong and provides an alternative mechanism; the hydrodynamics of a porous orifice (G) Tube. These discoveries resolve the puzzle of three clinical syndromes discovering its patho-etiology and new successful treatment; namely the Trans Urethral Resection of the Prostate (TURP) syndrome and acute dilution hyponatraemia, the Adult Respiratory Distress Syndrome (ARDS) and the Loin Pain Haematuria Syndrome (LPHS). The two new types of vascular shocks are volumetric overload shocks defined here.


Mini Review
The last 32 years of my career life were spent in investigating and reporting these articles. [1][2][3][4] The articles recognize two new types of socks and its treatment, proves that Starling's law for the capillary interstitial fluid transfer is wrong and provides an alternative mechanism; the hydrodynamics of a porous orifice (G) Tube. These discoveries resolve the puzzle of three clinical syndromes discovering its patho-etiology and new successful treatment; namely the Trans Urethral Resection of the Prostate (TURP) syndrome and acute dilution hyponatraemia, the Adult Respiratory Distress Syndrome (ARDS) and the Loin Pain Haematuria Syndrome (LPHS). The two new types of vascular shocks are volumetric overload shocks defined here.
On another subject Volumetric Overload Shock (VOS) is a condition caused by massive fluid infusions in a short time and is of two types; Type one (VOS1) and Type two (VOS2). VOS1 is induced by sodium-free fluid gain of 3.5-5 litres in one hour such as Glycine, Glucose, Mannitol and Sorbitol. It is known as the TURP syndrome [5] or hyponatraemic shock. VOS2 is induced by massive infusion of sodium-based fluids such as normal saline, Ringer, Hartmann, plasma and plasma substitutes that may complicate the therapy of VOS1. VOS2 also complicates fluid therapy in critically ill patients suffering from other known shocks such as hypovolaemic, haemorrhagic and septicaemic shocks and presents with the adult acute respiratory distress syndrome (ARDS) [6]. VOS2 is induced by the gain of 12-14 litres of sodium-based fluids when reported in ARDS. The occurrence of massive interstitial tissue oedema with congestion of vital organs, pleural and peritoneal effusion, in the presence of hypotension shock, casted doubt on Starling's law! These issues were investigated at the clinical and physiological/ physical fronts.
Two clinical studies aiming to understand the TURP syndrome and recognising VOS were done. A prospective clinical study on 100 consecutive TURP patients of whom the condition of TURP syndrome affected 10 patients with severe hypotension and bradycardia and severe acute dilution hyponatraemia of <120 mmol/l. Volumetric overload was the only significant factor in causing the condition.
The second clinical study involved a case series of 23 cases of the TURP syndrome manifesting as VOS1. The first 3 cases died as they were diagnosed and treated erroneously as one of the recognised shocks and treated with further volume expansion. The remaining 20 patients were correctly diagnosed as VOS and treated with hypertonic 5% sodium chloride or 8.4% Sodium Bicarbonate. Each patient passed 4-5 litres of urine followed by recovery from shock and coma. This treatment was successful in curing all patients bringing them back from dead.
The physical investigation involved studies of the hydrodynamics of the porous orifice (G) tube comparing it to that of Poiseulle's tube. Thousands of experimental measurements of pressures at various parts of a circulatory system incorporating the G tube in a chamber to mimic the capillary-interstitial fluid compartment. The effect of changing the proximal (arterial), the distal (venous) pressures and the diameter of the inlet on side pressure of the G tube and chamber pressure as well as the dynamic magnetic field like fluid circulation around the G tube. It is quite remarkable how this circulatory model mimic the circulatory system in heath and disease. This dynamic magnetic field like fluid circulation around the G tube and surrounding chamber provide adequate replacement for Starling's law. The physiological equivalent of this physical study was done on the hind limbs of sheep. It demonstrated that arterial pressure causes suction not filtration due to the effect of pre-capillary sphincter. Venous pressure augmented filtration and oedema.
Shock is a disturbance at the capillary cellular level impairing the capillary-interstitial fluid transfer; hindering delivery of oxygen and removal of waste products. The process is governed by Starling's law [7]. In this law the arterial pressure is considered the force causing capillary filtration! If this is true, how come that arterial hypertension though common never causes oedema? Starling based his hypothesis on Poiseuille work on strait uniform brass tubes. Latter evidence however demonstrated that the capillary is a porous narrow orifice (G) tube as it has a pre-capillary sphincter [8] and pores that allow the passage of plasma proteins [9]. As the capillary pores allow the passage of plasma molecules, nullifying the osmotyic pressure of plasma proteins i.e oncotic pressure does not exist, a call for reconsideration of Starling's hypothesis was previously made but there was no alternative at that time [10]. This replacement came to light when the hydrodynamics of the G tube were discovered.
The hydrodynamics of the G tube1,11 ( Figure 1) demonstrated that the proximal (arterial) pressure induces a negative side pressure gradient on the wall of the G tube causing suction most prominent over the proximal half and turns into positive pressure over the distal half. Incorporating the G tube in a Chamber (C), representing the interstitial space surrounding a capillary, demonstrated a rapid dynamic magnetic field-like fluid circulation between the C and G tube lumen. This is a mixing engine between C and G effecting rapid irrigation under negative pressure i.e. without flooding or oedema. Incorporating the G tube and C in a circulatory model driven by electric pump inducing proximal pressure similar to arterial pressure; causing suction from C into the lumen of G tube. The distal (venous) pressure augments filtration. This proves that the arterial pressure causes suction not filtration at the capillary interstitial fluid circulation, and hence Starling's law is wrong. The reported hydrodynamics of the G tube provide an adequate mechanism for the capillary interstitial fluid circulation. This illustrates how 2 new types of vascular shocks and a replacement of Starling's law were discovered. On another subject, this article [11,12] reports the overlooked link of Loin Pain Hematuria Syndrome Complicating Symptomatic Nephroptosis and the Results of a new curative surgery; Renal Sympathetic Denervation and Nephropexy Surgery. Two new signs namely; the IVU 7 sign (Figure 2) and tube stretch hypothesis were reported demonstrating that renal pedicle stretch causing ischaemia and neuropathy.  (4). Thus the fluid around G tube inside C moves in magnetic field-like fluid circulation (5) taking an opposite direction to lumen flow of G. tube. The inflow (arterial) pressure (1) and orifice (2) induce the negative side pressure energy creating the dynamic G-C circulation phenomenon that is rapid, autonomous and efficient in moving fluid out from the G tube lumen at (4), irrigating C at (5), then sucking it back again at (3), maintaining net negative energy pressure (7) inside C. The distal outflow (venous) pressure (6) enhances outflow at (4) and its elevation may turn the negative energy pressure (7) inside C into positive, increasing volume and pressure inside C chamber. This was based on a prospective study of 190 with Symptomatic Nephroptosis (SN) on erect IVU-E, 182 were females and 8 males. The mean age was 28.8, duration of symptoms 15.7 and hospital follow up 6.6 years. Patients showed no abnormality on IVU or ancillary imaging when supine. All patients showed renal drop of >1.5 vertebrae (>5cm) on erect IVU film. Other demonstrable pathology on erect IVP film included: pelviuretric junction kink affecting the right kidney in 116 (61.1%) and bilateral in 19