Abstract

Pain is a phenomenon wisely initiated by nature as a warning sign of a condition that may be detrimental to our bodies. The efforts of humankind to find the means to control pain presents as one of the greatest challenges in medicine. The main aim of this article is to list out the forgotten history and evolution of local anesthesia. The comfortable use of today’s local anesthetics was a gift from the past, where like in all areas of studies is a process of many trial and errors perfecting the techniques and compounds used.

Keywords: Local anesthesia; Pediatric anesthesia; History of anesthesia; Erythromycin

Abbreviations: CNS: Central Nervous System; NE: norepinephrine; DA: Dopamine; PABA: Para-Amino Benzoic acid