Causes & Treatments in Arthritis

When Two Diseases Cross their Paths: The Diagnostic Challenge of Rheumatoid Arthritis in Sickle Cell Disease Patients

  • Open or Close Isabel M McFarlane*

    Department of Internal Medicine, State University of New York, USA

    *Corresponding author: Isabel M McFarlane, Clinical Assistant Professor of Medicine, Associate Program Director Residency Program, Department of Internal Medicine, Division of Rheumatology, State University of New York Downstate Medical Center, New York, USA, Email: Isabel.Mcfarlane@downstate.edu

Submission: October 18, 2017; Published: March 12, 2018

Volume1 Issue1
March 2018


When evaluating joint complaints in adult sickle cell disease (SCD) patients, a number of sickle cell-based entities come to mind such as avascular necrosis, osteomyelitis, bone infarcts, and septic arthritis. However, another important cause of joint disease is to be considered, rheumatoid arthritis (RA), this diagnosis is generally overlooked and rarely considered. Anecdotal reports highlighted the occurrence of RA in SCD presenting as diagnostic challenges for cases with chronic inflammatory arthritis, joint effusions, erosive arthritis and non-gouty arthritis [1-3].

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