The Great Masquerader: Pulmonary Embolism

Acute pulmonary embolism (PE) and Acute Coronary Syndrome (ACS) are considered to be potentially life threatening. Prompt identification of etiology of symptoms can significantly reduce morbidity and mortality. Both the have signs and symptoms that are common to either presentations such as dyspnea, chest discomfort and hemodynamic instability. Electrocardiography (ECG) has been traditionally used to differentiate in the initial stages of work between ACS and PE. More recently T wave inversion has been identified as possible sign of underlying PE. We would like to report a 49-year-old gentleman who presented with chest pain and was initially diagnosed and treated ACS. In this case presentation we would like to present the clinical findings and briefly discuss the salient difference between the two presentations.


Introduction
Acute pulmonary embolism (PE) and Acute Coronary Syndrome (ACS) are considered to be potentially life threatening. Prompt identification of etiology of symptoms can significantly reduce morbidity and mortality. Both the have signs and symptoms that are common to either presentations such as dyspnea, chest discomfort and hemodynamic instability. Electrocardiography (ECG) has been traditionally used to differentiate in the initial stages of work between ACS and PE. More recently T wave inversion has been identified as possible sign of underlying PE. We would like to report a 49-year-old gentleman who presented with chest pain and was initially diagnosed and treated ACS. In this case presentation we would like to present the clinical findings and briefly discuss the salient difference between the two presentations.

Case Description
This is a 49-year-old gentleman, with well controlled hypertension and asthma, who presented with a two weeks history of generalized fatigue and flu like symptoms along with progressively increasing exertional dyspnea, nausea and chest tightness for the past day.
On Examination, his has a resting heart rate of 98 beats/minute, blood pressure of 118/63, afibrile, respiratory rate of 19 and oxygen saturation of 95% on room air. His ECG ( Figure  1) was consistent with T wave inversions in leads V1-V4 and had elevated troponins at 227 (normal< 40). Based on the work up, patient was initially referred for urgent interventional catheterization for acute coronary syndrome (ACS). Subsequent echocardiogram (video 1) demonstrated a dilated right ventricle (RV) with elevated pressures (Figure 2) with no regional wall motion abnormalities. Given the echocardiographic findings patient underwent a CT angiogram of the chest. He was found to have bilateral pulmonary embolism (PE) ( Figure  3). Diagnosis of Pulmonary Embolism was confirmed, and patient was started on direct acting oral anticoagulation (Rivaroxaban). Patient was discharged home and followed by respiratory team. His ensuing echo (after 3 months) showed resolution of RV impairment. As this was unprovoked PE patient was continued on 6 months of anticoagulation

Discussion
Acute pulmonary embolism (PE) is a highly prevalent condition with a broad clinical presentation, which is principally difficult to diagnose across the emergency departments (EDs) with resulting treatment failure and complications. Mortality in patients with pulmonary

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Wellens' syndrome is also characterized by classic T-waves found in precordial leads especially V2-V3. The classic T-waves are described as either deeply inverted or biphasic, especially V2-V3 (may include V1 -V4) during pain-free periods in a patient presenting with ACS [4,5]. Discovering Wellens' syndrome is imperative as 75% of patients will develop acute anterior wall MI [6,]. These findings are suggestive of a high-grade proximal stenosis of the left anterior descending artery. While both ACS and PE can present with T wave inversions and elevated troponins, it is critical to differentiate among them in early presentation.
Classical differences between ACS and PE findings on the ECG are as following: A.

B.
Negative T waves in lead III and V1 were present only in 1% of ACS

C.
Absence of T wave's inversion in lead 1 & a VL and presence in V1 is highly suggestive of Pulmonary Embolism.

Conclusion
This case study implicates the importance of holistic approach to the patients. Furthermore, early echocardiogram in patients presenting with chest pain might lead to improved and good outcomes. Lastly, this case specifically reminds a healthcare professional that even though acute coronary syndrome may be evident with ECG, some number of the patients do present with a more concomitant or other disease that increases the complication.