Abstract

Aim: Endorphins are endogenous morphine, neuropeptide, produced from pituitary gland in response to stress and pain. There are three types of endorphins are beta-endorphins, dynorphins, enkephalins binds to mu, kappa, delta receptors found on immune cells and nervous system. Betaendorphins is a most abundant endorphins synthesized and stored in the anterior pituitary gland.

Material and methods: To search and find out about endorphins and their mechanism of action in treatment of diseases such as cancer, autoimmune diseases and infectious diseases.

Results: It has got various activities such as immune stimulatory, anti-inflammatory, analgesic activity, delay aging, stress buster activity involved in preventive, promotive, therapeutic and palliative treatment of various diseases such as cancer, auto-immune diseases, infectious diseases.

Conclusion: Endorphins especially beta- endorphins involved in preventive, promotive, therapeutic and palliative, holistic treatment of various diseases such as cancer, auto-immune diseases, infectious diseases, without adverse effects and inexpensive.

Keywords: Cortisol; HPA-axis; P53; NF-KB; STAT-3; Noradrenaline

Abbreviations: IL-1: Interleukin 1; IL-2: Interleukin 2; IL-6: Interleukin 6; IL-12: Interleukin-12; TNF-oe: Tumor Necrosis Factor-Alpha: NF-kB: Nuclear Factor-kappa B receptor; STAT-3: Signal Transducer and Activator of Transcription-3; Th1: Type 1 helper cells; Th2: Type 2 helper cells; mmp-2,9: matrix-metallo proteases 2,9; Tregs: Regulatory T cells; IL-18: Interleukin 18; IFN-γ: Interferon Gamma; IL-10: Interleukin 10; CRH: Corticotrophic Releasing Hormone; HPA-Axis-Hypothalamo Pituitary Adrenal Axis