Abstract

Advancements in Bioequivalence & Bioavailability

Sensible Use of Technologies to Increase Solubility and Bioavailability in Formulation Development

Submission: February 13, 2018; Published: March 26, 2018

DOI: 10.31031/ABB.2018.01.000504

ISSN 2640-9275
Volume1 Issue1

Abstract

In drug development process, the formulation of drug and its bioavailability are the major concerns in getting approval to conduct clinical trials. A poor bioavailability and solubility property of a product leads to rejection and fail to reach the market. Poor bioavailability of drugs is due to various factors for example aqueous solubility, drug permeability, dissolution rate, first-pass metabolism, etc. [1]. The most leading factor of poor bioavailability is the low solubility and permeability. Therefore, there are extensive researches to study the bio pharmaceutics classification system (BCS) class II, III and IV and to develop new technologies to overcome the problem of poor solubility and/ or permeability. Alteration in drug delivery process may produce substantial changes in bioavailability and solubility of a drug. There are array of cutting edge techniques which are developed and have been used by some pharmaceutical companies to enhance the solubility and improve bioavailability. Identifying the need of appropriate technologies at the earlier stages of drug discovery may increase the chances of overall success rate of approval which in fact saves unnecessary expenditure and reduce the cost of drug development. The degree of solubility of a drug in a definite solvent is measured as the saturation concentration where adding more solute does not increase its concentration in the solution [2].

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