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Abstract
Advancements in Bioequivalence & Bioavailability
The Polymorphism Effect in Active Pharmaceutical Ingredients (API): A Issue Affecting on Bioavailability And Bioequivalence of Drugs
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Open or Close Lorenzo do Canto Visentin*
Nanobusiness Informação e Inovação Ltda, Brazil
*Corresponding author: Lorenzo do Canto Visentin, Nano Business Information and Innovation Ltd, Polo Tecnológico de Xerém, Building 32, Av. Nossa Senhora das Graças, Rio de Janeiro 25250-020, Brazil
Submission: February 02, 2018; Published: February 15, 2018
ISSN 2640-9275 Volume1 Issue1
Abstract
The chemical and physical properties of the active pharmaceutical ingredients (API) on solid-state form can be affected by polymorphism effect. This effect can have a significant influence on the apparent solubility of the drug substance. Polymorphic forms of API differ in their internal solid-state structure, these compounds show a different crystallographic arrangements and different H-bonds self-arrangements [1,2]. The consequences of this effect in a drug substance which may exists in various polymorphic forms are change aqueous solubilities and dissolution rates [3].
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