Nanobusiness Informação e Inovação Ltda, Brazil
*Corresponding author: Lorenzo do Canto Visentin, Nano Business Information and Innovation Ltd, Polo Tecnológico de Xerém, Building 32, Av. Nossa Senhora das Graças, Rio de Janeiro 25250-020, Brazil, Tel: +55-21-2145-3218, Email: firstname.lastname@example.org
Submission: February 02, 2018; Published: February 15, 2018
Volume1 Issue1 February 2018
The chemical and physical properties of the active pharmaceutical ingredients (API) on solid-state form can be affected by polymorphism effect. This effect can have a significant influence on the apparent solubility of the drug substance. Polymorphic forms of API differ in their internal solid-state structure, these compounds show a different crystallographic arrangements and different H-bonds self-arrangements [1,2]. The consequences of this effect in a drug substance which may exists in various polymorphic forms are change aqueous solubilities and dissolution rates .